Santa Maria Vacations from $243

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Your Santa Maria Vacation

Make planning your travels easy by reserving a vacation package to Santa Maria. Let us take care of all the details, so you can focus on appreciating everything this neighborhood has to offer. Can't wait to head out and see the sights during your trip to Santa Maria? Make sure you stop by nearby attractions like Banco Pichincha Monumental Stadium, Mall del Sol Commercial Center and San Marino Mall. Expedia will help you turn your ideal Santa Maria vacation into reality, no matter your travel plans or budget.

The Latest Santa Maria Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Hotel Mar Azul

$243

per person

Oct 31 - Nov 3

found 1 day ago

Roundtrip flight included

Quito (UIO) to Guayaquil (GYE)

9/10 Wonderful! (84 reviews)

Helpful host and cafe in the hotel a plus…

Reviewed on Sep 5, 2026

Hotel del Parque

Save 100% on your flight

$1,408

per person

Oct 30 - Nov 6

found 13 hours ago

Roundtrip non-stop flight included

Chicago (CHI) to Guayaquil (GYE)

9.8/10 Exceptional! (133 reviews)

Solo el camino al hotel. Nos quedábamos estancados con los zapatos. Lo demás excelente.

Reviewed on Sep 7, 2026

Hotel Río Guayas by Art Hotels Ecuador

Las Peñas

Save 100% on your flight

$2,034

per person

Nov 30 - Dec 7

found 9 hours ago

Roundtrip non-stop flight included

Chicago (CHI) to Guayaquil (GYE)

10/10 Exceptional! (5 reviews)

Mansión Alcázar Boutique Hotel

Downtown Cuenca

$713

per person

Nov 13 - Nov 18

found 1 day ago

Roundtrip flight included

Miami (MIA) to Guayaquil (GYE)

9.6/10 Exceptional! (380 reviews)

Nos encanto la propiedad y decoracion,el personal la atencion exelente,definitivamente regresaria,gracias por la atencion y la buena voluntad siempre de atudar

Reviewed on Sep 15, 2026

Hospedaje Casa Aida Victoria

Downtown Cuenca

Save 100% on your flight

$33,513

per person

Nov 23 - Nov 30

found 19 hours ago

Roundtrip non-stop flight included

New York (NYC) to Guayaquil (GYE)

No reviews

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria

A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

A statue of a soldier on a pedestal with a building in the background.

Downtown Guayaquil

Travelers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Moorish Clock Tower while you're in town.

A densely packed urban area with numerous buildings and a prominent tower on a hill.

Puerto Santa Ana

Well-liked for its restaurants and river views, you might stop by Santa Ana Hill and Numa Pompilio Llona Street while you're exploring Puerto Santa Ana and the surrounding neighborhoods.

A cityscape with colorful buildings, a prominent church, and a hill with residential structures.

Kennedy

1 out of top 10 points of interest in this area

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A densely packed hillside cityscape with colorful buildings and a prominent tower against a sunset sky.

Urdesa

Urdesa is well-liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Santa Maria Hotel Deals

Oro Verde Guayaquil

9 De Octubre Y Garcia Moreno Guayaquil Guayas

Fully refundableReserve now, pay when you stay

$95 nightly

$107 total

Sep 26 - Sep 27

9.6/10 Exceptional! (1,003 reviews)

"Great staff, clean room, wonderful breakfast"

Reviewed on Sep 17, 2026

Wyndham Guayaquil Puerto Santa Ana

Calle Numa Pompilio Llona S N Guayaquil Guayas

Fully refundableReserve now, pay when you stay

$115 nightly

$129 total

Oct 16 - Oct 17

9.4/10 Exceptional! (1,002 reviews)

"We arrived after a flight diverted from Quito. We checked best hotel in Guayaquil and this was right. Staff is great, food wonderful, and we felt safe in this city that has not a great safe review"

Reviewed on Sep 19, 2026

Holiday Inn Guayaquil Airport by IHG

Av. de Las Américas,junto al Aeropuerto Guayaquil Guayas

Fully refundable

$101 nightly

$114 total

Sep 26 - Sep 27

9.4/10 Exceptional! (1,002 reviews)

"Excellent service. Comfortable beds which is a priority above all since I travel internationally each month. Great food and service"

Reviewed on Sep 19, 2026

See all 444 properties in Santa Maria

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.